RESUMEN
O melanoma é uma neoplasia rara na população pediátrica, sendo ainda mais rara em crianças menores de 10 anos. O mapeamento corporal total constitui método não invasivo e de baixo custo, capaz de aumentar a acurácia diagnóstica na avaliação de lesões pigmentadas, principalmente em pacientes de alto risco. Relatamos um paciente de nove anos de idade com síndrome do nevo displásico, no qual uma lesão apresentou mudança sutil (assimetria de estruturas) no seguimento de seis meses. A exérese da lesão resultou em melanoma com Breslow 1mm e linfonodo-sentinela negativo. O mapeamento corporal total reduz o número de exéreses desnecessárias e permite o diagnóstico de melanomas em estágios iniciais e potencialmente curáveis, especialmente em crianças e pacientes com fatores de risco como síndrome do nevo displásico. O caso foi reportado devido à raridade da neoplasia na faixa etária e para demonstrar a importância da dermatoscopia digital seriada no diagnóstico precoce de melanoma nessa população.
Melanoma is a rare neoplasm in the pediatric population, and it is even rarer in children under 10 years of age. Total body mapping constitutes a low-cost and non-invasive method that increases diagnostic accuracy in evaluating pigmented lesions, especially in high-risk patients. We reported the case of a 9-year boy with dysplastic nevus syndrome, in which one lesion presented a subtle change (asymmetry of structures) within a 6-months follow-up. Its excision resulted in melanoma with a Breslow thickness of 1 mm and a negative sentinel lymph node. Total body mapping reduces the number of unnecessary excisions. It allows diagnosis of melanomas in early and potentially curable stages, especially in children and patients with risk factors such as dysplastic nevus syndrome. We report this case due to the rarity of the neoplasia in this age group and also to demonstrate the importance of sequential digital dermoscopy in early diagnosis of melanoma in this population.
RESUMEN
Abstract: Agminated nevus refers to the presence of multiple nevi grouped in a circumscribed skin area; it is rarely reported in the literature. This report presents the case of a 10-year-old female patient with a history of Langerhans cell histiocytosis, who presents multiple nevi in the lumbar and inguinal region. In the histopathological study, an atypical melanocytic nevus was reported. Wood's lamp examination discarded the presence of nevus spilus, and the diagnosis of agminated nevus was reached. The association of this type of nevus with Langerhans cell histiocytosis is rare, and only four cases were found reported in the indexed literature. The reason for this association is unknown, thus a new theory about its origin is presented here.
Asunto(s)
Humanos , Femenino , Niño , Neoplasias Cutáneas/patología , Histiocitosis de Células no Langerhans/patología , Nevo Pigmentado/patología , Dermoscopía , Región LumbosacraRESUMEN
Dysplastic nevus is common and affects about 10% of the northern European-descendent population. Studies over the past several decades have identified dysplastic nevi as a risk factor for malignant melanoma. Furthermore, in rare cases, they confirmed that dysplastic nevi have progressed to melanoma. Cases in which dysplastic nevi progressed to malignant melanoma in multiple studies are not uncommon. A 35-year-old woman presented with the major symptom of multiple itchy brown nodules (2.0 cm× 1.3 cm) in the left cheek that had first appeared 20 years earlier. Complete excision was performed at the first visit; subsequent biopsy confirmed that they were dysplastic nevi. They recurred three times over 3 years at the same site, all of which were histologically diagnosed as dysplastic nevi. Five years after the final excision, a brownish nodule developed in the left cheek, with others at the left temporal region, right retroauricular region, and left shoulder at the same time. These lesions were histologically diagnosed as malignant melanoma. We experienced a case of malignant melanoma that occurred at the same site after three recurrences of dysplastic nevi. Although rare, the possibility of malignant melanoma should be considered in follow-ups in cases involving repeatedly recurrent dysplastic nevi.
Asunto(s)
Adulto , Femenino , Humanos , Biopsia , Mejilla , Síndrome del Nevo Displásico , Estudios de Seguimiento , Melanoma , Recurrencia , Factores de Riesgo , Hombro , Lóbulo TemporalRESUMEN
Abstract: Several reports have demonstrated difficulties and lack of agreement in the histopathological diagnosis of particular melanocytic lesions, with problems in their management. A histogenetic approach to the study of these lesions originated the following classification: 1. superficial atypical proliferation significance; 2. melanocytic tumor of uncertain potential; 3. pigmented epithelioid melanocitoma of uncertain potential; 4. microinvasive radial growth phase of uncertain potential. The terminology remains controversial, reflecting the uncertainty of the diagnosis and the biological potential of these atypical melanocytic lesions.
Asunto(s)
Humanos , Neoplasias Cutáneas/diagnóstico , Melanocitos/patología , Melanoma/diagnóstico , Nevo Pigmentado/diagnóstico , Lesiones Precancerosas , Neoplasias Cutáneas/clasificación , Diagnóstico Diferencial , Melanoma/clasificación , Nevo Pigmentado/clasificación , Terminología como AsuntoRESUMEN
BACKGROUND: Digital dermoscopy is the gold standard follow-up method for patients with high risk for developing cutaneous malignant melanoma. By comparing the same lesion at different moments, it allows early detection of subtle changes that could suggest the diagnosis of melanoma. Thus, it is clear that the test must be repeated after a period of time, according to time intervals determined by the evaluator. OBJECTIVES: To evaluate adherence of patients to follow-up examinations using digital dermoscopy. METHOD: Retrospective analysis of 36 patients who underwent digital dermoscopic examination and total-body photography in a private medical center between September 2010 and January 2013. Results: Only 25% of the patients returned for followup evaluations. CONCLUSIONS: Low adherence to digital dermoscopy follow-up could compromise the efficacy of this valuable method. This lack of adherence represents a challenge for the evaluator. .
Asunto(s)
Adolescente , Adulto , Anciano , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Dermoscopía , Melanoma/diagnóstico , Nevo/diagnóstico , Cooperación del Paciente/estadística & datos numéricos , Neoplasias Cutáneas/diagnóstico , Estudios de Seguimiento , Estudios Retrospectivos , Factores de RiesgoRESUMEN
Asunto(s)
Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Síndrome del Nevo Displásico/patología , Nevo Pigmentado/patología , Neoplasias Cutáneas/patología , Brasil , Síndrome del Nevo Displásico/clasificación , Melanoma/patología , Clasificación del Tumor , Invasividad Neoplásica , Variaciones Dependientes del Observador , Reproducibilidad de los Resultados , Estudios RetrospectivosRESUMEN
O prognóstico do melanoma cutâneo depende principalmente de sua espessura, sendo a detecção precoce do melanoma extremamente importante para a maior sobrevida dos pacientes. Com a utilização do exame dermatoscópico, pode-se alcançar acurácia de aproximadamente 90%. Melanomas iniciais podem não apresentar características dermatoscópicas específicas, sendo apenas diagnósticados pela mudança ao longo do tempo, observada pelo mapeamento corporal total e dermatoscopia digital seriados. Os grupos que apresentam maior sensibilidade para detecção do melanoma com esse exame são os de portadores de síndrome do nevo atípico e melanoma múltiplo familial.
The prognosis of cutaneous melanomas depends mainly on the lesions' thickness; early detection is of paramount importance for patient longer survival rates. An accuracy of approximately 90% can be achieved using dermoscopic assessment. Since early melanomas might not present specific dermoscopic features, they can only be diagnosed by observing alterations over time through total body mapping and serial digital dermoscopy. Patients with atypical nevus syndrome and multiple familial melanoma presented a higher sensitivity for the detection of melanoma using that technique.
RESUMEN
Atypical Mole Syndrome is the most important phenotypic risk factor for developing cutaneous melanoma, a malignancy that accounts for about 80 percent of deaths from skin cancer. Because the diagnosis of melanoma at an early stage is of great prognostic relevance, the identification of Atypical Mole Syndrome carriers is essential, as well as the creation of recommended preventative measures that must be taken by these patients.
Asunto(s)
Humanos , Síndrome del Nevo Displásico/complicaciones , Melanoma/etiología , Neoplasias Cutáneas/etiología , Diagnóstico Diferencial , Síndrome del Nevo Displásico/patología , Diagnóstico Precoz , Melanoma/patología , Factores de Riesgo , Neoplasias Cutáneas/patologíaRESUMEN
Objective To investigate the expression of insulin-like growth factor-Ⅱ(IGF-Ⅱ) mRNAbinding protein-3 (IMP3) in tissue of benign nevi and malignant melanoma,and to evaluate the role of IMP3 in the development and diagnosis of malignant melanoma.Methods Immunohistochemistry was performed to measure the expression of IMP3 in tissue samples from 28 cases of malignant melanoma,8 Spitz nevi,6 dysplastic nevi and 25 benign nevi.Results Immunohistochemically,IMP3 was observed in 23 of 28 melanoma samples,4 of 8 Spitz nevus samples and 2 of 6 dysplastic nevus samples,but not in benign nevus samples.The expression level of IMP3 wag significantly higher in tissue of melanoma than in that of Spitz nevi and dysplastic nevi (both P<0.05),also higher in tissue of aggressive melanoma than that of melanoma in situ(P<0.01).Conclusions IMP3 seems to be a biomarker for the progression of benign nevi to malignant melanoma,and may be utilized to distinguish melanoma from benign nevi.
RESUMEN
Nevus depigmentosus is a stable and well-circumscribed congenital hypomelanosis that may be in an isolated, dermatomal or systemic form. An 18-yr-old Korean man with segmental nevus depigmentosus developed multiple pigmented nevi which were present only within the confines of the leukoderma. Histologic and electron microscopic studies rendered a diagnosis of nevus depigmentosus with dysplastic nevus to the patient. The genetic alteration of melanocytes in the hypopigmented lesion is assumed to have resulted in the development of multiple pigmented nevi.